Figure 6

Syntenic relationships of the conserved HR domain in birds, humans and mice. Physical maps of human, mouse, rat and chicken genomic sequences were used to identify genes neighboring the conserved HR domains. Each diagram represents a chromosomal region whose position is defined by the number of base pairs from the telomere of the short arm of the chromosome (top and bottom of each diagram). Each horizontal line represents the position of a gene and is placed in physical order on the chromosome. Diagrams are depicted in such a way that genes are oriented in the same way. A) The HR domains were syntenic in human (chromosome 6q27) and mouse (chromosome 17). They share 50% identity with the chicken HR domain of transitin located on chromosome 25 (see Fig. 3). B) A corresponding gene cluster was found on chicken chromosome 3 from which an "avian" HR domain genomic segment was absent. RHGB, Rhesus blood group, B glycoprotein; HAPLN2, hyaluronan and proteoglycan link protein 2; BCAN, brevican; PRCC, papillary renal cell carcinoma; SH2D2A, SH2 domain protein 2A; ARHGEF11, Rho guanine nucleotide exchange factor (GEF) 11 and CD244, CD244 natural killer cell receptor 2B4; PDCD2, programmed cell death 2; PSMB1, proteasome (prosome, macropain) subunit, beta type, 1; TCTE3, t-complex-associated-testis-expressed 3; PDE10A, phosphodiesterase 10A; QKI, quaking homolog; SOD2, superoxide dismutase 2; THBS2, thrombospondin 2, PACRG, PARK2 co-regulated and WDR27, WD repeat domain 27.