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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Error-threshold exists in fitness landscapes with lethal mutants

Figure 3

Equilibrium population distribution with high lethality. Similar plots as in Fig. 2, but with high lethality of mutants. The figure displays the existence of the error-threshold, and the delocalization of the population from the fittest genotype. The blue dashed line is placed in Fig. 3(A,B) at the error rate for which d log y0/d(1 - q) is locally minimum as depicted in (C). For all graphs, the parameters are as follows. ν = 50. f d = 0.99d. κ = 0.05; however, for each G MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFge=raaa@382C@ d , Round ( κ ( ν d ) ) / ( ν d ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcgaqaamaabmaabaacciGae8NUdS2aaeWaaeaafaqabeGabaaabaGae8xVd4gabaGaemizaqgaaaGaayjkaiaawMcaaaGaayjkaiaawMcaaaqaamaabmaabaqbaeqabiqaaaqaaiab=17aUbqaaiabdsgaKbaaaiaawIcacaGLPaaaaaaaaa@3938@ is used as the actual value of κ in Eq. (2), where Round(x) is the closest integer of x. (Thus, κ = 0 for G MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaat0uy0HwzTfgDPnwy1egaryqtHrhAL1wy0L2yHvdaiqaacqWFge=raaa@382C@ ν , and then f ν is set to zero to be consistent).

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