Gene conversion limits divergence of mammalian TLR1 and TLR6

Table 2 Pattern of codon usage for conserved amino acids between TLR1 and TLR6

Species	Amino acid region 1–436	Amino acid region 437–744	Amino acid region 745 – end
Homo sapiens	57.2 (n = 215)	93.6 (n = 280)	57.1 (n = 35)
Pan troglodytes	56.3 (n = 213)	94.5 (n = 291)	61.8 (n = 34)
Macaca mulatta	58.5 (n = 207)	96.9 (n = 295)	62.5 (n = 32)
Mus musculus	52.1 (n = 188)	97.7 (n = 302)	43.8 (n = 32)
Rattus norvegicus	50.0 (n = 180)	97.7 (n = 304)	42.4 (n = 33)
Erinaceus europaeus	55.9 (n = 186)	97.7 (n = 304)	80.0 (n = 30)
Bos Taurus	58.0 (n = 212)	96.7 (n = 303)	80.6 (n = 36)
Sus scrofa	56.3 (n = 208)	94.4 (n = 302)	82.9 (n = 41)
Canis familiaris	61.8 (n = 191)	97.7 (n = 298)	71.4 (n = 35)
Average ± SD	56.2 ± 3.5 *	96.3 ± 1.7 *	64.7 ± 15.3 *

For three regions of TLR1 and TLR6 (amino acids 1 to 436, amino acids 437 to744 and amino acids 745 to end) we determined, for all conserved amino acids, whether the codon used in TLR1 or TLR6 was identical or synonymous. The results are expressed as identical/(identical + synonymous) × 100%. n : gives the number of conserved amino acids on which the averages were calculated.
* The percentage identical codon usage for conserved amino acids for the region 437–744 was significantly higher than for the regions 1–436 and 745-end.

ISSN: 2730-7182