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Figure 13 | BMC Evolutionary Biology

Figure 13

From: Ancient intron insertion sites and palindromic genomic duplication evolutionally shapes an elementally functioning membrane protein family

Figure 13

The short region of the alignment of 115 AA sequences to illustrate exclusively conserved AA sites among the tunicate and vertebrate GIRK group. Alignment: HR-115IRK-LXXG. The region corresponded to 24 amino acid residues from W329 and H352 in the C-terminal domain of human Kcnj5 (GIRK4). Purple-colored characters, L339 in human Kcnj5, indicate strict and exclusive conservation, except tunicate GIRKBs. The Leucine residue in mouse Kcnj6 (GIRK2) has been suggested to be the most effective previous activation sites by G-protein beta and gamma [35].

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