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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Molecular evolution of the MAGUK family in metazoan genomes

Figure 4

Evolutionary model of the MAGUK subfamily-structure evolution. Evolving from a catalytically active GK encoding gene, the family arose by obtaining both a PDZ and SH3 domain. Then the MPP subfamily branched off, assimilating L27 domains and, in the case of CASK, also a kinase domain. The MPP subfamily member known as MPP1 evolved last and lost its L27 domains. The CACNB and MAGI subfamilies arose through domain loss of the PDZ and SH3 domains, respectively. The later one also obtained WW domains, most likely resulting in a C-terminal truncation of the GK domain. The MAGUK core structure, consisting of a PDZ, SH3 and GK domain evolved further and gave rise, after duplication of the most C-terminal PDZ domain, to the DLG, ZO and, lastly, the CARMA subfamily. This PDZ domain duplicated another time at the birth of the DLG5 structure. The arrowheads on the bottom indicate two different gene duplication events. Arrows on top of the protein structures show PDZ domain duplication events derived from our phylogeny.

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