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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Molecular evolution of the MAGUK family in metazoan genomes

Figure 3

Molecular modeling of guanylate kinase domains based on the human sequences. Indicated in the left, uppermost panel are the three dynamic domains of the GMP guanylate Kinase: the GMP binding sub-domain, the CORE sub-domain and the LID sub-domain. The other panels show modeled structures of the MAGUK subfamilies, superimposed by Swiss Model. Arrows indicate the likely course of the structural evolution. The relationships established through our phylogenetic analysis are reflected here in the comparison of structures for the human representatives. The MPP structure still has a resemblance close to the human GMP guanylate Kinase, having a similar orientation of the three sub-domains of the GMP GK. The DLG and ZO subfamilies are also very closely related, when the presented 3D structures are compared. The MAGI GK could only be partially superimposed on known structures, sharing at least the GK GMP binding domain with the other MAGUK subfamilies. The used PDB files are listed in Additional file 2. The lowest four panels show representative models of the GK-HOOK-SH3 super domains of the MAGUK subfamilies MPP, DLG, ZO and CACNB. As in the upper panels the GK domain is colored yellow and magenta (β-strands and helices respectively), while the SH3 and HOOK regions are colored green and blue.

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