Figure 2

Guanylate kinase dendrogram and summarized phylogenetic analyses. (A) The dendrogram is based on all protein families currently known to contain GK sequences (note: this is not a phylogeny). These include the three families of the voltage-gated calcium channel beta subunit (CAB), the homologs of Guanylate kinase (GUK) and the MAGUK family. The core structure of the GUK is GK only, while the CAB and MAGUK families have a SH3-GK or PDZ-SH3-GK architecture respectively. The MAGUK and CAB families were only found in metazoan species, while sequences of GUK family members appeared dispersed over all eukaryotic lineages. In the GUK clade the metazoans are indicated with the letter M, the Fungi with F, Bacteria with B, Viruses with V and the Plants with P. Species that were included in this dendrogram as well as sequences used are listed in Additional file 2. (B-C) Summarized phylogenetic trees based on Bayesian consensus trees (see Additional file 3, 4, 5) for the GK, SH3 and PDZ domains, respectively. Numbers indicate % Bayesian posterior probability and % bootstrap Maximum Likelihood.