Figure 5

Conservation of crucial intracellular motifs in zebrafish Class I receptor chains. Multiple sequence alignments of the intracellular regions of homologues of GP130 (a), LIFR and OSMR (b), and IL-7Rα (c) from zebrafish, human and mouse. The solid lines above the alignments indicate key regions of conservation: Box 1, Box 2, Box 3, serine rich (SR), and the internalization motifs. The dashed line under the consensus sequence represents conserved docking sites for the signaling molecules SHP-2/Socs3, Stat3, and Stat5.