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Table 2 Comparative genomics of the sodium channel β2 gene in zebrafish and mammals.

From: Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

gene

Genbank accession number

gene location

cDNA

exon 1

exon 2

exon 3

exon 4

exon 5

exon 6

protein

%ID (%SIM)

topology

zβ2A

DQ489726

Chr 15

821

243 (82)

167

411 (234)

-

-

-

160

32.6% (42.5%)

IG(V): 47–152

TM: none

zβ2B

DQ489727

Chr 15

2449

243 (82)

167

217

196

68 (10)

1558 (0)

223

49.6% (64.7%)

IG(V): 47–152

TM: 162–186

zβ2C

DQ489728

Chr 15

851

243 (82)

167

217

124

100 (13)

-

201

45.2% (58.4%)

IG(V): 47–152

TM: 162–186

zβ2D

DQ489729

Chr 15

918

243 (82)

167

217

193

98 (34)

-

231

48.1% (62.8%)

IG(V): 47–152

TM: 162–186

Hsβ2

NM_004588

Chr 11

4939

260 (70)

167

211

4301 (200)

-

-

215

100% (100%)

IG(V): 43–146

TM: 156–180

Mmβ2

NM_001014761

Chr 9

3980

213 (70)

167

211

618 (200)

2771 (0)

-

215

92.1% (94.4%)

IG(V): 43–146

TM: 156–180

Rnβ2

NM_012877

Chr 8

873

236 (70)

167

211

259 (200)

-

-

215

93.0% (94.9%)

IG(V): 43–146

TM: 156–180

  1. Presentation and labeling as in Table 1. %ID (%SIM) refers to percentage identity and similarity with the human β2 protein sequence as determined by alignment. Zebrafish β2 subunit topology was determined as described in Methods. Numbering refers to β2 protein sequence with signal peptide intact. IG(V) domain and transmembrane regions for human β2 and human/mouse/rat splice variants were annotated based on previous reports [11, 14, 43, 101].