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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes

Figure 4

Loop and segment sizes joining transmembrane regions and canonical NADPH-oxidase domains. After alignment of canonical and TM domains, the numbers of amino acids linking these regions were counted. I to VI in boxes indicate the six predicted TM α-helices, and FAD-binding subregions (FAD1 and FAD2) and the four NADPH-binding subregions (NADPH1 to NADPH4) are shown. Solid lines show the relative length of loops and linkers that are characteristic of specific Nox subfamilies. The numbers of amino acids are indicated. Broken lines show the average lengths. More detailed information on the number of residues linking each of the canonical regions for each Nox subtype is provided in Additional file 1.

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