Skip to main content
Figure 1 | BMC Evolutionary Biology

Figure 1

From: Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes

Figure 1

Schematic domain structures of Nox family. (A) The Nox domain possesses 6 transmembrane α-helices (I through VI in boxes), two hemes ("heme" in diamonds), and predicted sub-regions that provide binding cavities for a co-enzyme FAD (FAD1 and FAD2) and for a substrate NADPH (N-I, N-II, N-III, and N-IV). (B) All members of Nox/Duox family contain the Nox domains. Abbreviations are: "EF" refers to any domain containing one or more EF-hand motifs; "peroxidase" refers to a region that is homologous to a heme-containing peroxidase; "N" refers to an asparagine-rich region; "4 × TM", four predicted transmembrane α-helical segments; "At-rbohD" is A. thaliana respiratory burst oxidase homolog-D; "Ag" is A. gambiae; "Dd" is D. discoideum; "Mg" is M. grisea; "Cc" is C. crispus.

Back to article page