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Table 5 Role of the positively selected sites in the discrepancy between feruloyl esterase A and lipase activities.

From: Tracking the connection between evolutionary and functional shifts using the fungal lipase/feruloyl esterase A family

Three dimensional localization Positively selected sites Site directed mutagenesis & Role on Lip/FAE discrepancy References
1. Flap region (69–80) 71,75,78,80 80 catalysis and substrate discrimination [45,46]
2. Catalytic vicinity 100 100 substrate recognition [47]
3. Loop (226–244) 236,238,244 - structured plasticity to the substrate binding site [23,48]