Tracing the origin of functional and conserved domains in the human proteome: implications for protein evolution at the modular level

Table 6 Some commonly occurring functional domain combinations (not ordered) in protein sequences with multiple Pfam-A annotations

F^a	Different domain combinations	N^b
2	Kruppel-associated box & Zf-C2H2 zinc finger family	316
	Immunoglobulin superfamily & Marek's disease glycoprotein A	206
	IKI3 family & WD-40 repeats	149
3	G-protein alpha subunit & G-protein superfamily & Dynein light intermediate chain	131
	MHC_I & MHC_II_beta & immunoglobulin superfamily	50
	POZ domain superfamily & recombination activating protein 2 & kelch repeat superfamily	50
4	MHC_I & MHC_II_beta & immunoglobulin superfamily & MHC_I_C	66
	Cation transporter/ATPase, N-terminus & E1-E2 ATPase & haloacid dehalogenase (HAD) superfamily & Cation transporter/ATPase, C-terminus	38
	C. elegans chemosensory receptor & Frizzled/OA1/CAR/Secretin receptor-like (FOCS) superfamily & mammalian taste receptor protein(TAS2R) & Family A G protein-coupled receptor-like superfamily	36
5	C. elegans chemosensory receptor &C.elegans Srg family integral membrane protein & Frizzled/OA1/CAR/Secretin receptor-like (FOCS) superfamily & mammalian taste receptor protein(TAS2R) & Family A G protein-coupled receptor-like superfamily	659

ISSN: 2730-7182