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Table 6 Some commonly occurring functional domain combinations (not ordered) in protein sequences with multiple Pfam-A annotations

From: Tracing the origin of functional and conserved domains in the human proteome: implications for protein evolution at the modular level

Fa Different domain combinations Nb
2 Kruppel-associated box & Zf-C2H2 zinc finger family 316
  Immunoglobulin superfamily & Marek's disease glycoprotein A 206
  IKI3 family & WD-40 repeats 149
3 G-protein alpha subunit & G-protein superfamily & Dynein light intermediate chain 131
  MHC_I & MHC_II_beta & immunoglobulin superfamily 50
  POZ domain superfamily & recombination activating protein 2 & kelch repeat superfamily 50
4 MHC_I & MHC_II_beta & immunoglobulin superfamily & MHC_I_C 66
  Cation transporter/ATPase, N-terminus & E1-E2 ATPase & haloacid dehalogenase (HAD) superfamily & Cation transporter/ATPase, C-terminus 38
  C. elegans chemosensory receptor & Frizzled/OA1/CAR/Secretin receptor-like (FOCS) superfamily & mammalian taste receptor protein(TAS2R) & Family A G protein-coupled receptor-like superfamily 36
5 C. elegans chemosensory receptor &C.elegans Srg family integral membrane protein & Frizzled/OA1/CAR/Secretin receptor-like (FOCS) superfamily & mammalian taste receptor protein(TAS2R) & Family A G protein-coupled receptor-like superfamily 659
  1. a F = Number of functions associated with a protein sequence
  2. b N = Number of occurrences of corresponding combination