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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis

Figure 4

Detailed trees for the AR/HB-EGF and TR1/TR2 pairs. (A) The AR/HB-EGF pair from the tree in Fig. 3. HB-EGF exists in both teleosts and tetrapods, but there is no teleost AR, while the teleosts do have a second sequence labeled AHP, which is slightly more similar to HB-EGF than to AR. (B) The TR1/TR2 pair from the tree in Fig. 3. This tree shows an additional duplication pattern with both TR1 and TR2 forms in the teleosts segregating together. This tree is complicated by the different ligand length for TR2 in the teleosts compared to the rest of the ligands on this branch. The difference in length does suggest an alteration in the sequence requirement for TR2 in the teleosts. (C) Tomoregulin 1 and 2 sequences from human and zebrafish. These sequences are representative of the sequences from other species. TR2 is two amino acids shorter in the zebrafish than the other sequences. Reverse text (white text on black background) denotes residues that are at least 75% conserved between the four ligands, with grey shaded text (black text on grey background) denoting residues that are different at these conserved positions.

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