Figure 3
From: Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis
Phylogenetic relationship of the EGF modules from the vertebrate ErbB ligands. The tree shown was generated using neighbor joining with poisson correction of protein sequences in MEGA version 3.1 [61]. Each colored oval highlights the cluster of branches for a different ligand. Shown are some of the bootstrap percentages for the split between the two ligand families. Though the bootstrap percentages show low confidence in some of the branches of the tree, trees generated using different methods of distance correction exhibited similar separation of EGF receptor ligands and ErbB3/ErbB4 ligands and the positions of ligands relative to each other were comparable. Similar trees were generated using the Phylip [62] group of programs.