Global similarity and local divergence in human and mouse gene co-expression networks

Table 6 Correlation (r) between pairwise GO similarity and pairwise gene expression profile r-values

Network	r ¹	n ²	z ³	P ⁴
Human-specific	0.0581	43933	9.47	0
Mouse-specific	0.0730	52315	8.51	0
Intersection	0.1927	5370

¹Pearson correlation coefficient
²Number of gene pairs compared
³Value of the test statistic for the comparison between the species-specific network and the intersection network, z = (zf 1-zf 2)/sqrt(1/(n 1–3)+1/(n 2–3)) where zf is the Fisher transform, zf = 1/2*ln((1+r)/(1-r))
⁴Level of significance, i.e., probability that the correlations in the intersection and species-specific networks are indistinguishable, based on normal distribution with infinite degrees of freedom

ISSN: 2730-7182