Figure 4

Protein size is constrained by the size requirements of the functional domain. Comparing S. cerevisiae biochemical activity annotation data and protein size A) Biochemical activity classes with a disproportionate representation among the largest proteins (length>771 amino acids). Probability (p) of a deviation from the representation among all proteins is displayed (hypergeometric distribution). Significant (p < 0.001) deviations are indicated; red = overrepresentation, green = underrepresentation. B) Biochemical activity classes with a deviating (p < 0.001) representation in any size interval. N-fold overrepresentation (red) and underrepresentation (green) as compared to the expected representation are indicated.