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Table 1 The twelve families of universally conserved genes missing in mammals

From: Eleven ancestral gene families lost in mammals and vertebrates while otherwise universally conserved in animals

Gene Family Name1 A.t2 S.c2 A.g2 D.m2 C.e2 Loss extends to Function EC KEGG pathway
ACH 0 1 1 1 1 Deutero. Acetyl-CoA Hydrolase, Pyruvate Metabolism 3.1.2.1 sce00620
TPS 4 1 1 1 2 Deutero. Trehalose 6P biosynthesis 2.4.1.15 Sce00500
YD56 4 3 2 1 1 Chordates Multicopper Ion transporter 1.-.-.- XXX
YMT1 1 1 1 3 1 Chordates Putative oxidroeductase and K+ ion transporter XXX XXX
PNC1 0 1 1 1 1 Chordates Nicotinate and Nicotinamide Metabolism 3.5.1.19 sce00760
YM74 3 2 1 1 1 Chordates Transcription factor activity/DNA Binding XXX XXX
THDH1/ILV1 1 1 1 1 2 Chordates Leucine, Isoleucine, Valine Biosynthesis. Threonine Metabolism 4.3.1.19 sce00260
GLT 1 1 1 1 1 Chordates Glutamate synthesis 1.4.1.13 sce00251 sce00910
AMT/MEP -1,2,3 6 3 1 1 4 Eu-chordates Amonium Transporter XXX XXX
YKH1 0 1 1 1 9 Mammals Metabolism, oxidoreductase XXX XXX
URH1 2 1 3 3 2 Mammals Uridine catabolism, hydrolase activity 3.2.2.3 XXX
  1. 1 Gene family name is given according to the gene's name in Saccharomyces cerevisiae.
  2. 2 Number of gene copies from the considered family present in the genome, for each model species, A.t = Arabidopsis thaliana, S.c = Saccharomyces cerevisiae, A.g = Anopheles gambiae, D.m = Drosophila melanogaster, C.e = Caenorhabditis elegans.
  3. 3 KEGG's biochemical pathway's accession number for Saccharomyces cerevisiae.