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Figure 4 | BMC Evolutionary Biology

Figure 4

From: A protein evolution model with independent sites that reproduces site-specific amino acid distributions from the Protein Data Bank

Figure 4

Full symbols and lines indicate average properties of protein folding thermodynamics in SCN simulations, open symbols indicate the same quantities in the proteomes of different bacterial species [39]. The horizontal axis represents the GC mutation bias for SCN simulations and the GC content at third codon position of the bacterial genes, (a) Mean hydrophobicity. SCN results are rescaled by a factor 8.6 and correspond to three single-domain proteins, lysozyme (PDB code 31zt, circles), phosphocarrier protein Hpr (PDB code 1opd, diamonds), and myoglobin (PDB code 1a6g, squares), and for the small two-domain protein ATP synthase ε unit (ATPE, PDB code 1aqt, triangles), (b) Mean unfolding free energy. SCN results are rescaled by a factor 4.3. Only ATPE is represented, the other proteins being qualitatively equivalent. (c) Mean normalized energy gap. SCN results are rescaled by a factor 1.3. Only ATPE is represented, the other proteins being qualitatively equivalent.

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