Figure 8

Model for the evolution of vertebrate TSPs, based on evidence of protein sequence phylogeny, conserved synteny of genomic loci between species, and paralogous relationships between the genomic regions of human TSPs. The diagram also takes into account that the A and B forms predate the whole genome duplications that occurred early in the vertebrate lineage [5]. TSP genes and proteins are indicated in black and their genomic contexts in blue. Dotted line indicates that intermediate steps are not represented for TSP-1 and TSP-2. See Discussion for details.