Figure 7

Paralogous relationships of TSP-encoding loci in the human genome. The database of Paralogons in the human genome, version 5.28, was searched for evidence of large-scale similarities of genomic organization in the chromosomal regions of the five thrombospondin genes. Panels A to E show the five paralogous blocks identified, their chromosomal locations, and the gene pairs that make up each block. The genomic regions of subgroup B TSPs are strongly related, the TSP-1 and TSP-4 loci are marginally related and the TSP-2 gene is located within an unrelated region of the genome. In each block, the paired TSP genes are labeled in red. Other genes present in multiple blocks are underlined. Genes are identified according to HUGO gene nomenclature where available, or by the GenBank accession number of the encoded predicted protein. In B, gene order on chromosome 19 is displayed in an expanded view.