Rate of promoter class turn-over in yeast evolution

Table 2 Evolution of class 1 (TATA box-containing) promoters between S. cerevisiae and other species of sensu stricto group

Species	Conserved ORFs	Switches of promoter type	Switches of promoter type per gene of this class per Ks^a	TATA boxes shifted	TATA box shift events per TATA-containing gene per Ks^a	Average conservation of upstream intergenic region
1. TBP-sensitive, TATA-containing genes (N = 212)
paradoxus	200 (94.3%)	2	0.05	0	0.00	0.85
mikatae	180 (84.9%)	7	0.13	0	0.00	0.74
kudriavtsevii	179 (84.4%)	8	0.13	0	0.00	0.71
bayanus	178 (84.0%)	4	0.06	2	0.03	0.66
2. Non-TBP-sensitive, TATA-containing genes (N = 34)
paradoxus	30 (88.2%)	8	1.40	0	0.00	0.79
mikatae	31 (91.2%)	10	1.08	0	0.00	0.73
kudriavtsevii	26 (76.5%)	14	1.58	0	0.00	0.65
bayanus	23 (67.6%)	9	1.09	2	0.24	0.63
3. Non-TBP-sensitive, non-TATA-containing genes (N = 322)
paradoxus	278 (86.3%)	14	0.27	-	-	0.82
mikatae	241 (74.8%)	22	0.30	-	-	0.71
kudriavtsevii	218 (67.7%)	11	0.15	-	-	0.67
bayanus	238 (73.9%)	9	0.11	-	-	0.64

^a Number of events per time required for the accumulation of one nucleotide substitution at a non-coding site. The average number of substitutions per nucleotide site in intergenic regions, relative to S. cerevisiae, is 0.19 in S. paradoxus, 0.30 in S. mikatae, 0.34 in S. kudriavtsevii, and 0.36 in S. bayanus.

ISSN: 2730-7182