TY - JOUR AU - Karboul, Anis AU - Gey van Pittius, Nicolaas C. AU - Namouchi, Amine AU - Vincent, VĂ©ronique AU - Sola, Christophe AU - Rastogi, Nalin AU - Suffys, Philip AU - Fabre, Michel AU - Cataldi, Angel AU - Huard, Richard C. AU - Kurepina, Natalia AU - Kreiswirth, Barry AU - Ho, John L. AU - Gutierrez, M. Cristina AU - Mardassi, Helmi PY - 2006 DA - 2006/12/12 TI - Insights into the evolutionary history of tubercle bacilli as disclosed by genetic rearrangements within a PE_PGRS duplicated gene pair JO - BMC Evolutionary Biology SP - 107 VL - 6 IS - 1 AB - The highly homologous PE_PGRS (Proline-glutamic acid_polymorphic GC-rich repetitive sequence) genes are members of the PE multigene family which is found only in mycobacteria. PE genes are particularly abundant within the genomes of pathogenic mycobacteria where they seem to have expanded as a result of gene duplication events. PE_PGRS genes are characterized by their high GC content and extensive repetitive sequences, making them prone to recombination events and genetic variability. SN - 1471-2148 UR - https://doi.org/10.1186/1471-2148-6-107 DO - 10.1186/1471-2148-6-107 ID - Karboul2006 ER -