Table 2 Conservation of functionally important amino acid residues (FIRs).
From: Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans
Functional Site Type (# of residues) | Ce-GnRHR vs. human GnRHR1 | Ce-GnRHR vs. Dm-AKHR | Human GnRHR1 vs. Dm-AKHR | Ce-GnRHR vs. human Rhodopsin | Ce-GnRHR vs. human Vasopressin receptor |
|---|---|---|---|---|---|
Receptor activation (6) | 83.3% | 83.3% | 83.3% | 75.0% | 83.3% |
Ligand binding (7) | 35.7% | 21.4% | 42.9% | 7.1% | 35.7% |
Binding pocket formation (24) | 54.2% | 68.8% | 72.9% | 43.8% | 33.3% |
PKC phosphorylation (2) | 50.0% | 75.0% | 50.0% | 25.0% | 50.0% |
Gq/11 G-protein coupling (8) | 62.5% | 93.8% | 68.8% | 56.2% | 62.5% |
Gs G-protein coupling (3) | 50.0% | 33.3% | 33.3% | 0.0% | 33.3% |
Total similarity (FIRs only) | 56.0% | 66.0% | 66.0% | 41.0% | 44.0% |
Identity (all residues) | 20.8% | 26.6% | 20.4% | 12.4% | 17.9% |
Identity + Similarity (all residues) | 36.3% | 45.2% | 37.9% | 28.5% | 34.4% |