Figure 3

Comparison of population structure between analytical predictions and computer simulations The fraction of the fittest phenotype population is plotted against the error rate per base (1 - q). The black line (the solid line with error bars) is obtained from computer simulations. The red line (the solid line without error bars) is calculated with the additive assumption from Eq. 1 and Eq. 2 with σ = 10 and N = 76 as in the simulations. λ is set to be 0.4 which is the time averaged representative λ value observed in the simulations after the population evolves (see the Methods section – Non-uniform distribution of λ – for the definition of the representative λ). The green line (the dotted line) is obtained from the formulation of Reidys et al. [5] with the same parameters as the above. The blue line (the dashed line) is calculated with the four λ approximation by using λ values reported in [5] (λ = 0.2489 on average) and σ = 10 and N = 76 as in our simulations.