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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Phenotypic error threshold; additivity and epistasis in RNA evolution

Figure 2

Information threshold The solid lines represent the maximum maintainable sequence length (Nmax) plotted against λ, where Nmax is calculated by using Eq. 4 where σ = 2, 10 and 100 (as indicated within the figure) and q = 0.95. The value of q was chosen to be plausible for ribozyme polymerization [14]. These solid lines show the dependence of Nmax on λ; on the other hand, the dependence of λ on N (the length of sequence) is examined by calculating the average λ in RNA folding for various values of N. The filled circles represent so obtained λ values as a function of N. In obtaining λ, a neutral substitution is defined as a single base substitution which does not alter the secondary structure of a focal sequence. For each sequence length, a hundred randomly generated RNA sequences are examined. In RNA folding program [7], the default parameters are used (in the all occasions in the study).

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