Table 8 Animal-specific clusters
Cluster size (# of sequences) | Max. edge (P-score) | protein family | putative function/site of action | organism |
|---|---|---|---|---|
39 | 9.9E-7 | Spectrins, Dystrophin, Nesprins | membrane/actin/MT crosslinkers (cytoskeleton) | C.e., D.m., H.s., M.m. |
32 | <E-40 | Laminins | scaffold protein (extracellular matrix) | C.e., D.m., H.s., M.m. |
25 | 6.7E-8 | Plectin/Desmoplakin | actin/MT crosslinkers (cytoskeleton) | C.e., D.m., H.s., M.m. |
22 | 6.5E-8 | Myosin heavy chain (muscle) | actin motor protein, muscle fibers | C.e., D.m., H.s., M.m. |
18 | 9.3E-9 | Lamins | nuclear IFs | C.e., D.m., H.s., M.m. |
17 | 5.8E-7 | Neurofilament triplet L, M, Death inducer, Troponin T | C.e., D.m., M.m., H.s. | |
14 | 7.5E-7 | Neurofilament triplet H, M | C.e., D.m., H.s., M.m. | |
14 | 7.5E-7 | Neurofilaments (Desmin, Vimentin) | IFs | C.e., H.s., M.m. |
13 | 2.6E-7 | PP1, ASPP | apoptosis stimulating | D.m., H.s., M.m. |
12 | <E-40 | Moesin, Ezrin, Radixin | membrane organization and stabilization (membrane cytoskeleton, cytovilli) | C.e., D.m, H.s., M.m. |
11 | 1.7E-43 | RUFY | possible role in vesicle trafficking (endosomes?) | D.m., H.s., M.m. |
11 | 2.2E-11 | Lamins | nuclear IFs | D.m., H.s., M.m. |
11 | 3.4E-7 | Restin, Dynactin, CLIP proteins | linking endocytic vesicles to MTs (IF cytoskeleton), dynein activator (MTs in neurons), MT/IF associated (cytoskeleton) | C.e., D.m., H.s., M.m. |
11 | 3.9E-7 | Png-1, Neurofilament triplet M, Troponin T | C.e., D.m., H.s., M.m. | |
10 | <E-40 | Dystrophins | C.e., D.m., H.s., M.m. | |
10 | 2.7E-8 | prion-like protein | C.e., D.m. |