Unusual linkage patterns of ligands and their cognate receptors indicate a novel reason for non-random gene order in the human genome

Table 4 Incidences of occurrence, on the same mouse chromosome, of a ligand with one of its cognate receptors after removal of tandem duplicates by Blast and position methods. The distance is defined as the span between the mid-positions of the ligand and the mid-position of the receptor. The receptors indicated with a Y in the conserved linkage column are those that are also on the same chromosome as the same ligand in the comparable human genome set (i.e. those in Table 1).

Class	Gene	Unigene #	Chromosome	Distance (Mb)	Conserved linkage
Ligand	Jag1	Mm.22398	2
Receptor	Notch1	Mm.290610	2	110.41
Ligand	Dll4	Mm.143719	2
Receptor	Notch1	Mm.290610	2	92.67
Ligand	Bmp2	Mm.103205	2
Receptor	Acvr1	Mm.689	2	74.85
Receptor	Acvr2	Mm.314338	2	84.49
Ligand	Bmp7	Mm.595	2
Receptor	Acvr1	Mm.689	2	114.51
Receptor	Acvr2	Mm.314338	2	124.15
Ligand	Tnfsf8	Mm.4664	4
Receptor	Tnfrsf8	Mm.12810	4	81.45
Ligand	Pdgfa	Mm.2675	5
Receptor	Pdgfra	Mm.221403	5	62.52
Ligand	Ptn	Mm.279690	6
Receptor	Ptprz1	Mm.41639	6	13.86	Y
Ligand	Fgf15	Mm.3904	7
Receptor	Fgfr2	Mm.16340	7	14.87
Ligand	Mst1	Mm.8369	9
Receptor	Mst1r	Mm.3901	9	0.17	Y
Ligand	Ifng	Mm.240327	10
Receptor	Ifngr1	Mm.549	10	98.83
Ligand	Fgf10	Mm.317323	13
Receptor	Fgfr4	Mm.276715	13	61.47	Y
Ligand	Bmp4	Mm.6813	14
Receptor	Bmpr1a	Mm.237825	14	8.55
Ligand	Dll1	Mm.4875	17
Receptor	Notch3	Mm.4945	17	16.56
Receptor	Notch4	Mm.173813	17	18.88	Y

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