Skip to main content

Table 2 Examples of horizontally transferred genes in TT and DR

From: Comparative genomics of Thermus thermophilus and Deinococcus radiodurans: divergent routes of adaptation to thermophily and radiation resistance

Selected horizontally transferred genes/operons T. thermophilus Protein ID D. radiodurans Protein ID Comment
Xenologous gene displacement
Ribosomal protein L15 (COG0200) TTC1309 DR2115 Proteobacterial affinity of DR; Affinity to Thermatoga/Aquifex/other Gram-positive bacteria in TT
Ribosomal protein L30/L7E (COG1841) TTC1310 DR2114 Thermatogales/Aquifecales version in TT, affinity to other bacteria in DR
Thiamine biosynthesis protein ThiC (COG0422) TTC0319 DRA0175 Proteobacterial affinity in DR; Cyanobacteria/Actinobacterial affinity in TT
Threonine synthase (COG0498) TTC0117 DRA0360 Proteobacterial version in DR; Cyanobacteria/Actinobacterial affinity in TT
Trk system potassium uptake protein trkG, trkA (COG0168, COG0569) TT0809, TT0810 DR1667, DR1668; DR1666 Archaeal version in TT; Gram-positive version in DR
Ribonucleoside-diphosphate reductase alpha chain and beta chains (COG0208, COG0209) TTP0162, TTP0161 DRB0108, DRB0109 Proteobacterial affinity for TT; affinity with Gram-positive bacteria in DR
Paralogous genes acquisition
5-formyltetrahydrofolate cyclo-ligase (COG0212) TTC1247, TTC1803 DR1815 Gram-positive version in DR and TT; additional pseudoparalog TT1803 appears to be of archaeal origin
Non-orthologous gene displacement/acquisition
Thymidylate synthase TTC0731 (COG1351) DR2630 (COG0207) Represented by two non-homologous genes in DR (protobacterial version) and TT (orthologs in Treponema, Wolbachia)
Purine-nucleoside phosphorylase (purine degradation enzyme) TTC1070 (COG0813) TTC0194 (COG0005) DR2166 (COG0813) TT has two non-homologous enzymes; TTC0194 probably was acquired from a thermopilic source