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Table 1 Gene and transcript annotation of protein-coding genes located on human chromosome Xq22.1-q22.2. Human WEX1 has arisen from duplication of WEX2, and human BEX5 is absent from the mouse genome. a Levels of transcript expression in the brain are based on Microarray gene hybridization results [57]. Accession codes and expression tags are shown in parentheses. A gene expression in the brain is absent (-), present (+), or high relative to other tissues (++). Abbreviations: GLA, Galactosidase, alpha; HNRPH2, Heterogeneous nuclear ribonucleoprotein H2; GASP, G protein-coupled receptor-associated sorting; NXF, Nuclear RNA export factor; PRAMEL3, Preferentially expressed in melanoma like 3; WEX, WWbp5-like gene family; BEX, B rain-e xpressed X-linked; TCP11B, T-complex 11 B; TMSNB, Thymosin, beta, identified in neuroblastoma; RAB40A, Ras oncogene family member; MSP, Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit); KIRL2, Killer immunoglobulin-like receptor-like 2; KIR3DL1, Killer immunoglobulin-like receptor 3DL1; MORF4L2, Mortality factor 4 like 2;

From: Mammalian BEX, WEX and GASP genes: Coding and non-coding chimaerism sustained by gene conversion events

RefSeq Gene RefSeq Protein Synonyms Gene name Gene Start Gene End Transcriptional orientation Expression in the braina (accession/expression-tag) BGW element
NM_000169 NP_000160   GLA 99424654 99434808 - + (GLA/214430_at)  
NM_019597 NP_062543   HNRPH2 99435140 99440975 + + (HNRPH2) +
NM_152583 (BC036206) NP_689796 Q8K2R3 GASP4 99512319 99560303 + + (gnf1h06491_at) +
NM_016608 NP_057692 Alex1/Q9P291 GASP7 99577371 99581530 + + (ARMCX1) +
    GASP10ψ 99624346 99624903 + N/A +
NM_019007 NP_061880 Q9NWJ3 GASP10 99641972 99644848 - + (FLJ20811) +
NM_016607 NP_057691 Alex3, Q9UH62 GASP6 99649976 99654688 + + (ARMCX3) +
NM_177949 NP_808818 Alex2, O60267 GASP9 99682129 99686692 - + (ARMCX2) +
NM_032946 NP_116564   NXF5 99858942 99884406 - N/A  
AK094141 XP_040486   KIAA1789 99910469 99958857 - N/A  
NM_080390 (AL540086) NP_525129 my048 WEX1 100152572 100154538 + ++ (AF063606) +
BC071675 N/A   WEX2 100167309 100169228 - N/A +
BC042818 N/A   BEX5 100180542 100182792 - N/A +
NM_017809 (BX647232) NP060279   NXF2 100242137 100353489 + + (NXF2/220257_x_at)  
NM_017809 (BX647232) NP060279   NXF2 100387175 100498589 - + (NXF2/220257_x_at)  
NM_021992 NP_068832   TMSNB 100540461 100543504 - ++ Fetal brain (205347_s_at)  
NM_207512 NP_997395   NXF4 100576750 100598478 + N/A  
NM_022838 NP_073749 Q9H969 GASP5 100626014 100630940 + + (FLJ12969/219335_at)  
NM_014710 NP_055525 Q43168 GASP1 100678299 100685235 + ++ (GASP/204793_at)  
NM_138437 (AK123832) NP_612446 Q96D09 GASP2 100739148 100744517 + N/A  
NM_030639 NP_085142 Q9BE11 GASP3 100747511 100779225 + + (KIAA1701/213709_at)  
    Rab40A-like 100964038 100965103 + ++ (108_g_at)  
NM_018476 (BX098763) NP_060946 BEX1, HBEX2 BEX2 101089445 101090956 - ++ (BEX1/218332_at) +
NM_022052 NP_071335   NXF3 101102606 101119879 - - (NXF3/220110_s_at)  
AK000959 N/A Bex4 BEX4 101241922 101243977 + ++ (BEXL1/ 215440_s_at, 40916_at**)  
NM_153333 (AL709034) NP_699164 Wex3 WEX3 101279783 101281945 - N/A +
AL550633 N/A Wex4 WEX4 101300507 101303513 - ++ (gnf1h07374_s_at, gnf1h07373_at) +
NM_032621 (AL520932) NP_116010 Bex2, mouseBex1 BEX1 101336132 101337663 - N/A  
NM_152278 (H09952) NP_689491 Wex5 WEX5 101357022 101359108 + ++ (gnf1h06733_at) +
NM_016303 (BF028506) NP_057387 Wex6 WEX6 101383280 101385238 + + (WBP5 / 217975_at) +
NM_206915 NP_996798 Ngfrap1 BEX3 101403125 101404856 + ++ (NGFRAP1/217963_s_at) +
NM_080879 NP_543155   RAB40A 101526538 101546274 - N/A (RAB40A, 217589_at, 33477_at)  
NM_024863 (AK024827) NP_079139 Wex7 WEX7 101603016 101614300 + ++ (FLJ21174) +
NM_032926 NP_116315 Wex8 WEX8 101634691 101636711 + ++ (MGC15737) +
NM_004780 NP_004771 TCEAL1 WEX9 101655759 101657725 + ++ (TCEAL1) +
NM_012286 NP_036418   MORF4L2 101702290 101713453 - + MORF4L2