Figure 4From: The iron-sulfur cluster assembly genes iscS and iscU of Entamoeba histolytica were acquired by horizontal gene transferModel of the active site of E. histolytica IscS and Thermotoga maritima NifS. The E. histolytica IscS putative three-dimensional structure (A) was deduced using the conceptually translated iscS sequence. The previously solved crystal structure of T. maritima NifS (B) [PDB accession number: 1EG5, [32]] was used as a template. The E. histolytica IscS sequence was aligned to the T. maritima NifS sequence using DeepView v3.7 [http://www.expasy.org/spdbv/, [60]] and manually improved based on an independent Clustal W alignment [54]. Only residues involved in co-factor (PLP) and substrate (Cys) binding were selected in order to show the active site.Back to article page