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Table 1 Effect of mutations on kinetic parameters of substrate hydrolysis by single mutations. Data were fitted on equation derived from scheme 1. Only parameters significantly modified in mutated proteins are shown.

From: Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance

  Wild type I161V G265A F330Y G368A
k2 (s-1) 19000 15000 67000 30000 28000
k3 (s-1) 400 154 860 120 180
K p (μM) 180 - - - 300
K L 1 - - - 16
K LL 127 - 400 1150 -
a 4.2 - - - -
b 0.16 - - - -
k dec (10-6 s-1) 108 57 122 61 59