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Table 5 Effects of different patterns of mutation combinations on insecticide resistance represented as ki ratio (ki reference/ki mutant enzyme).

From: Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations

  1 mutation 2 mutations 3 mutations 4 mutations
Alleles IGYG VGFG IAFG IGFA VGYG IAYG IGYA VAFG VGFA IAFA VAYG VGYA IAYA VAFA VAYA
methyl-azinphos oxon 2.2 0.92 3.2 0.87 0.49 5.3 2.0 5.0 1.8 40 4.8 5.1 16 77 17
carbaryl 1.9 0.93 1.9 0.46 1.9 0.88 2.1 2.7 0.58 3.9 12 1.6 7.3 7.2 5.4
carbofuran 2.3 0.52 1.8 1.8 1.0 1.0 2.4 1.7 0.62 1.4 4.3 1.4 7.2 3.9 3.3
chlopyriphos oxon 1.7 0.80 1.5 10 0.92 5.5 5.7 1.9 4.5 10 11 2.9 23 30 8.6
coumaphos oxon 3.0 3.9 38 0.25 0.40 190 7.5 51 4.7 64 1100 210 230 95 250
diazinon oxon 91 1.9 2.2 1.3 2.2 45 4.7 12 7.0 32 8.3 640 13 3.7 12
dichlorvos 4.4 1.4 1.9 1.0 0.23 0.40 9.1 2.2 1.2 14 9.0 7.6 4.8 16 30
omethoate 0.35 0.95 1.0 8.4 0.66 1.2 2.8 0.71 21 39 12 11 21 14 29
malaoxon 3.9 6.4 1.7 10 1.0 5.7 37 16 6.5 40 32 48 83 1900 5900
methamidophos 2.53 0.29 4.2 11 2.53 2.65 16 1.8 5.9 76 0.37 150 84 150 290
methiocarbe 0.77 0.50 3.6 2.1 0.67 7.0 0.92 2.4 0.34 4.5 4.0 0.45 16 7.8 5.0
monocrotophos 0.58 0.78 5.6 2.1 0.13 0.69 2.3 8.7 0.44 30 5.9 4.9 6.7 46 21
paraoxon 2.2 2.3 8.9 8.7 6.0 10 4.3 41 4.7 67 330 9.1 47 97 93
methyl-paraoxon 2.3 3.4 6.5 11 0.28 3.7 2.4 2.1 1.3 86 14 5.4 26 31 58
pirimicarbe 2.6 1.3 5.6 5.3 0.83 6.9 2.4 32 3.7 40 28 3.2 42 42 56
propoxur 4.1 1.2 1.5 0.91 0.76 8.6 2.1 1.1 0.37 3.5 5.5 1.4 8.0 2.7 3.7
triazophos oxon 5.9 1.7 0.90 1.8 0.55 0.89 2.8 1.6 0.65 13 16 5.7 6.8 4.4 17
  1. The most resistant alleles for each insecticide are in bold. All differences exceeding a factor of 2, (below 0.5 or above 2) are significant.