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Table 5 Effects of different patterns of mutation combinations on insecticide resistance represented as ki ratio (ki reference/ki mutant enzyme).

From: Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations

 

1 mutation

2 mutations

3 mutations

4 mutations

Alleles

IGYG

VGFG

IAFG

IGFA

VGYG

IAYG

IGYA

VAFG

VGFA

IAFA

VAYG

VGYA

IAYA

VAFA

VAYA

methyl-azinphos oxon

2.2

0.92

3.2

0.87

0.49

5.3

2.0

5.0

1.8

40

4.8

5.1

16

77

17

carbaryl

1.9

0.93

1.9

0.46

1.9

0.88

2.1

2.7

0.58

3.9

12

1.6

7.3

7.2

5.4

carbofuran

2.3

0.52

1.8

1.8

1.0

1.0

2.4

1.7

0.62

1.4

4.3

1.4

7.2

3.9

3.3

chlopyriphos oxon

1.7

0.80

1.5

10

0.92

5.5

5.7

1.9

4.5

10

11

2.9

23

30

8.6

coumaphos oxon

3.0

3.9

38

0.25

0.40

190

7.5

51

4.7

64

1100

210

230

95

250

diazinon oxon

91

1.9

2.2

1.3

2.2

45

4.7

12

7.0

32

8.3

640

13

3.7

12

dichlorvos

4.4

1.4

1.9

1.0

0.23

0.40

9.1

2.2

1.2

14

9.0

7.6

4.8

16

30

omethoate

0.35

0.95

1.0

8.4

0.66

1.2

2.8

0.71

21

39

12

11

21

14

29

malaoxon

3.9

6.4

1.7

10

1.0

5.7

37

16

6.5

40

32

48

83

1900

5900

methamidophos

2.53

0.29

4.2

11

2.53

2.65

16

1.8

5.9

76

0.37

150

84

150

290

methiocarbe

0.77

0.50

3.6

2.1

0.67

7.0

0.92

2.4

0.34

4.5

4.0

0.45

16

7.8

5.0

monocrotophos

0.58

0.78

5.6

2.1

0.13

0.69

2.3

8.7

0.44

30

5.9

4.9

6.7

46

21

paraoxon

2.2

2.3

8.9

8.7

6.0

10

4.3

41

4.7

67

330

9.1

47

97

93

methyl-paraoxon

2.3

3.4

6.5

11

0.28

3.7

2.4

2.1

1.3

86

14

5.4

26

31

58

pirimicarbe

2.6

1.3

5.6

5.3

0.83

6.9

2.4

32

3.7

40

28

3.2

42

42

56

propoxur

4.1

1.2

1.5

0.91

0.76

8.6

2.1

1.1

0.37

3.5

5.5

1.4

8.0

2.7

3.7

triazophos oxon

5.9

1.7

0.90

1.8

0.55

0.89

2.8

1.6

0.65

13

16

5.7

6.8

4.4

17

  1. The most resistant alleles for each insecticide are in bold. All differences exceeding a factor of 2, (below 0.5 or above 2) are significant.