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Table 5 Comparison of the true hits among the top 10 predicted sites for ANCESCON, evolutionary trace (ET), simple conservation (SC), and conservation difference (CD) methods

From: Reconstruction of ancestral protein sequences and its applications

Protein Family PDB ID# Ligand/ substrate Number of sites * ** *** ANCESCON ET SC CD
adkinase 1aky AP5 188 42 20 18 3 9.5 9.1 8
gef 1bkd H-Ras 245 47 4 0 3 3 3 2
globin 1a6g HEM 147 21 1 1 2 5.5 6 6
pdz 1be9 + 81 15 2 1 6 4 4 2
ph 1mai I3P 109 11 2 0 2 2 3 2
ptb 1shc PTR 157 27 2 1 6 5 5 9
ras 821p GTN 185 29 10 9 2 5.6 8.7 5
sh2 1a09 ACE 83 17 2 1 3 5 4 4
sh3 1nlo ACE 57 9 1 1 2 5 4 0
subtilase 1av7 SBL 278 22 8 4 5 4.6 3.8 4
  1. #:Representative protein structure
  2. *: Number of sites within 5Å to ligand or substrates
  3. **: Number of invariant sites, which may contain gaps
  4. ***: Number of invariant sites within 5 Å to ligand or substrates
  5. +: C-terminal peptide of protein CRIPT