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Table 1 Pairwise BLAST comparisons with C. elegans AADCs.

From: Function and evolution of the serotonin-synthetic bas-1 gene and other aromatic amino acid decarboxylase genes in Caenorhabditis

 

C05D2.4

C05D2.3

F12A10.3*

K01C8.3

ZK829.2

C09G9.4

Ce GAD

C05D2.4

(bas-1)

Score

%Id / %Sim

-

-

-

-

-

-

C05D2.3

1674

59 / 75

-

-

-

-

-

-

F12A10.3*

1756

60 / 77

1793

63 / 78

-

-

-

-

-

K01C8.3

(tdc-1)

970

37 / 57

844

34 / 54

733

33 / 51

-

-

-

-

ZK829.2

583

29 / 47

541

27 / 46

559

27 / 49

1147

44 / 66

-

-

-

C09G9.4

224

22 / 40

150

18 / 38

190

19 / 40

272

22 / 42

275

23 / 44

-

-

Ce GAD

(unc-25)

210

22 / 38

164

20 / 36

216

23 / 37

299

25 / 43

250

24 / 41

129

20 / 40

-

Dm DDC

1095

41 / 60

909

36 / 56

984

38 / 58

1390

50 / 69

883

37 / 57

256

22 / 42

328

24 / 40

Hs DDC

1067

41 / 60

912

36 / 55

949

38 / 58

1458

55 / 73

935

39 / 59

233

20 / 42

322

26 / 44

Dm HisDC

996

39 / 57

816

33 / 53

807

32 / 54

1348

52 / 70

910

40 / 59

278

23 / 42

339

26 / 44

Hs HisDC

988

38 / 56

802

33 / 53

876

34 / 56

1290

48 / 69

920

39 / 59

231

21 / 42

306

26 / 42

Dm G30446

971

38 / 57

845

34 / 53

686

30 / 50

1671

64 / 77

1008

40 / 62

254

20 / 44

n.s.

Dm AMD

961

38 / 57

799

35 / 53

668

36 / 53

1124

44 / 63

741

33 / 51

201

20 / 40

278

25 / 41

Dm G30445

837

34 / 52

797

35 / 53

814

33 / 53

1407

55 / 71

905

39 / 57

259

22 / 42

n.s.

Cr TrpDC

743

30 / 51

674

28 / 50

735

30 / 52

916

37 / 59

269

31 / 51

272

24 / 43

333

25 / 42

Dm GAD

226

22 / 39

207

21 / 38

232

22 / 41

374

27 / 43

226

22 / 41

99

25 / 55

1146

44 / 64

Hs GAD67

215

22 / 36

173

19 / 36

192

21 / 36

324

24 / 44

228

24 / 41

86

16 / 41

1535

56 / 73

  1. Comparisons of bas-1/C05D2.4 and other pyridoxal-phosphate dependent decarboxylase amino acid sequences were made using "BLAST 2 Sequences" [version 2.2.6, http://www.ncbi.nlm.nih.gov/blast/bl2seq/bl2.html [73]; Settings (largely default): Matrix – BLOSUM62, Open gap penalty – 11, extension gap penalty – 1, low complexity filtering – OFF). As shown in the table above, on the top line, each comparison shows the blast score; below is the percent identity and percent similarity for the 'alignable' sequence. The highest scoring match (excluding among C. elegans AADCs) is indicated in bold. Sequences in the left column are arranged in order of blast score in comparison to C05D2.4 C. elegans AADCs are indicated by their predicted gene designation: C05D2.4, C05D2.3, F12A10.3, K01C8.3, ZK829.2 and C09G9.4. Abbreviations: CeC. elegans, CrCaranthus roseus (periwinkle plant), DmDrosophila melanogaster, HsHomo sapiens, DDC – dopa decarboxylase, HisDC – histidine decarboxylase, AMD – Alpha-methyl dopa hypersensitive protein, TrpDC – tryptophan decarboxylase, GAD – glutamate decarboxylase. *An amino acid sequence for F12A10.3 was generated from cDNA sequence by introducing 2 frameshifts to preserve AADC homology in the predicted aa sequence merely for sake of comparison to other AADC's (see text); this sequence is different from predicted sequences in found in Genbank and Wormbase which are based on incorrect cDNA predictions.