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Table 1 Pairwise BLAST comparisons with C. elegans AADCs.

From: Function and evolution of the serotonin-synthetic bas-1 gene and other aromatic amino acid decarboxylase genes in Caenorhabditis

  C05D2.4 C05D2.3 F12A10.3* K01C8.3 ZK829.2 C09G9.4 Ce GAD
C05D2.4
(bas-1)
Score
%Id / %Sim
- - - - - -
C05D2.3 1674
59 / 75
- - - - - -
F12A10.3* 1756
60 / 77
1793
63 / 78
- - - - -
K01C8.3
(tdc-1)
970
37 / 57
844
34 / 54
733
33 / 51
- - - -
ZK829.2 583
29 / 47
541
27 / 46
559
27 / 49
1147
44 / 66
- - -
C09G9.4 224
22 / 40
150
18 / 38
190
19 / 40
272
22 / 42
275
23 / 44
- -
Ce GAD
(unc-25)
210
22 / 38
164
20 / 36
216
23 / 37
299
25 / 43
250
24 / 41
129
20 / 40
-
Dm DDC 1095
41 / 60
909
36 / 56
984
38 / 58
1390
50 / 69
883
37 / 57
256
22 / 42
328
24 / 40
Hs DDC 1067
41 / 60
912
36 / 55
949
38 / 58
1458
55 / 73
935
39 / 59
233
20 / 42
322
26 / 44
Dm HisDC 996
39 / 57
816
33 / 53
807
32 / 54
1348
52 / 70
910
40 / 59
278
23 / 42
339
26 / 44
Hs HisDC 988
38 / 56
802
33 / 53
876
34 / 56
1290
48 / 69
920
39 / 59
231
21 / 42
306
26 / 42
Dm G30446 971
38 / 57
845
34 / 53
686
30 / 50
1671
64 / 77
1008
40 / 62
254
20 / 44
n.s.
Dm AMD 961
38 / 57
799
35 / 53
668
36 / 53
1124
44 / 63
741
33 / 51
201
20 / 40
278
25 / 41
Dm G30445 837
34 / 52
797
35 / 53
814
33 / 53
1407
55 / 71
905
39 / 57
259
22 / 42
n.s.
Cr TrpDC 743
30 / 51
674
28 / 50
735
30 / 52
916
37 / 59
269
31 / 51
272
24 / 43
333
25 / 42
Dm GAD 226
22 / 39
207
21 / 38
232
22 / 41
374
27 / 43
226
22 / 41
99
25 / 55
1146
44 / 64
Hs GAD67 215
22 / 36
173
19 / 36
192
21 / 36
324
24 / 44
228
24 / 41
86
16 / 41
1535
56 / 73
  1. Comparisons of bas-1/C05D2.4 and other pyridoxal-phosphate dependent decarboxylase amino acid sequences were made using "BLAST 2 Sequences" [version 2.2.6, http://www.ncbi.nlm.nih.gov/blast/bl2seq/bl2.html [73]; Settings (largely default): Matrix – BLOSUM62, Open gap penalty – 11, extension gap penalty – 1, low complexity filtering – OFF). As shown in the table above, on the top line, each comparison shows the blast score; below is the percent identity and percent similarity for the 'alignable' sequence. The highest scoring match (excluding among C. elegans AADCs) is indicated in bold. Sequences in the left column are arranged in order of blast score in comparison to C05D2.4 C. elegans AADCs are indicated by their predicted gene designation: C05D2.4, C05D2.3, F12A10.3, K01C8.3, ZK829.2 and C09G9.4. Abbreviations: CeC. elegans, CrCaranthus roseus (periwinkle plant), DmDrosophila melanogaster, HsHomo sapiens, DDC – dopa decarboxylase, HisDC – histidine decarboxylase, AMD – Alpha-methyl dopa hypersensitive protein, TrpDC – tryptophan decarboxylase, GAD – glutamate decarboxylase. *An amino acid sequence for F12A10.3 was generated from cDNA sequence by introducing 2 frameshifts to preserve AADC homology in the predicted aa sequence merely for sake of comparison to other AADC's (see text); this sequence is different from predicted sequences in found in Genbank and Wormbase which are based on incorrect cDNA predictions.