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Table 3 Correlation between ortholog substitution levels and the substitution levels between the most closely related paralogs

From: Duplicated genes evolve slower than singletons despite the initial rate increase

Speciesa

Slopeb

r2c

P d

Human – Mouse

6.1 × 10-2

3.3 × 10-2

3.3 × 10-87

Drosophila – Anopheles

6.5 × 10-2

2.3 × 10-2

7.6 × 10-27

S. cerevisiae – C. albicans

2.1 × 10-1

1.0 × 10-1

1.1 × 10-38

E. coli – Y. pestis

3.3 × 10-2

3.0 × 10-3

9.0 × 10-2

B. subtilis – B. halodurans

1.6 × 10-1

4.2 × 10-2

3.1 × 10-11

P. horikoshii – P. furiosis

6.3 × 10-2

1.7 × 10-2

1.0 × 10-3

  1. a Species for which comparisons were performed b Slope of the linear regression line (i.e. y from the equation y = mx + b) c Square of the correlation coefficient (corresponds to the fraction of variation in ortholog evolutionary rates explained by the variation in paralog evolutionary rate) d P-value for correlation coefficient