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Table 2 Correlation between ortholog substitution levels and the number of paralogs

From: Duplicated genes evolve slower than singletons despite the initial rate increase

Speciesa

Slopeb

r2c

P d

Human – Mouse

-1.0 × 10-4

3.0 × 10-3

7.2 × 10-13

Drosophila – Anopheles

-8.0 × 10-4

5.2 × 10-3

9.6 × 10-10

S. cerevisiae – C. albicans

-4.7 × 10-3

9.8 × 10-3

6.0 × 10-9

E. coli – Y. pestis

-6.0 × 10-4

3.0 × 10-4

4.2 × 10-1

B. subtilis – B. halodurans

-7.0 × 10-4

2.0 × 10-4

4.9 × 10-1

P. horikoshii – P. furiosis

-2.5 × 10-3

1.5 × 10-3

1.4 × 10-1

  1. a Species for which comparisons were performed b Slope of the linear regression line (i.e. y from the equation y = mx + b) c Square of the correlation coefficient (corresponds to the fraction of variation in ortholog evolutionary rates explained by the variation in the number of paralogs) d P-value for correlation coefficient