Figure 1

Average substitution levels, with 95% confidence intervals, for orthologous human-mouse sequence pairs with paralogs (duplicates – light gray bars) and with no paralogs (singletons – dark gray bars). The x-axis labels indicate comparisons where orthologous pairs were classified as duplicates or singletons based on three criteria: 1 – presence of a paralog in the human genome alone (Human), 2 – presence of a paralog in the mouse genome alone (Mouse) and 3 – presence of a paralog in the human or mouse genome (Human & Mouse). a – amino acid substitution levels calculated using the gamma correction for multiple substitutions. b – ratio of non-synonymous (dN) to synonymous (dS) nucleotide CDS substitutions.