Figure 1

Phylogenetic analysis of the TACC family members compared to other coiled coil proteins. The phylogenetic tree was constructed as described in the Methods section. The TACC family defines a separate subfamily of coiled coil containing proteins, distinct from other coiled coil families such as the keratins, RHAMM and tropomyosins. Note that the RHAMM proteins form a separate branch more closely related to the tropomyosins and kinesin like proteins (KLP), than the TACC proteins.