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Table 1 Quantile analysis of mass spectrometry protein interaction data. Genes were separated into 1–5 bins based on their expression levels [15]. Each column is an analysis of the data set with a different number of bins. Each row is the rank of each bin's average expression level, where low rank indicates low expression. The upper number in each cell is the Spearman rank correlation coefficient between number of interactions and evolutionary rate (rEI). The lower number in each cell is the partial correlation coefficient between number of interactions and evolutionary rate, controlling for expression level (rEI.A); the three cases in which this number has a greater absolute value than rEI are underlined.

From: Evolutionary rate depends on number of protein-protein interactions independently of gene expression level

 

1

2

3

4

5

1

-0.403***

-0.223***

-0.182*

-0.179*

-0.206*

 

-0.277***

-0.216***

-0.182*

-0.179*

-0.205*

2

 

-0.341***

-0.323***

-0.245**

-0.192*

  

-0.285***

-0.328***

-0.272**

-0.197*

3

  

-0.263***

-0.366***

-0.352***

   

-0.258**

-0.358***

-0.336**

4

   

-0.225*

-0.357***

    

-0.222*

-0.325**

5

    

-0.253*

     

-0.207*

  1. *, p < 0.05; **, p < 0.005; ***, p < 0.0005.