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Table 1 Inferences from phylogenetic analysis of Runt domain sequences*

From: The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organisms

  NEIGHBOR PROML PROTPARS MRBAYES
Monophyly of deuterostome homologues? Yes (71 % bootstrap support for the deepest branch) Yes Yes for vertebrates and urochordates (74%), ambiguous for echinoderms Yes (93 % posterior probability)
Runx3 basal in vertebrates? No No No No
Deepest deuterostome branch is a single-copy gene? Yes Yes Yes Yes
Deepest protostome branch is a single-copy gene? Unclear (unresolved topology of the nematode and spider paralogues) Unclear (unresolved topology of the nematode and spider paralogues) Unclear (unresolved topology of the nematode and spider paralogues) Unclear (unresolved topology of the nematode and spider paralogues)
  1. *Inferences from trees constructed using neighbour-joining (NEIGHBOR), maximum likelihood (PROML), maximum parsimony (PROTPARS), and Bayesian inference of phylogeny (MRBAYES) algorithms, as described in Methods. The PROML and PROMLK programs produced identical results.