Figure 1From: The tyranny of adenosine recognition among RNA aptamers to coenzyme AAffinity matrices used in isolation of aptamers to adenosine cofactors. A) CoA attached to sepharose solid support through its pantotheine arm (disufide-linked CoA resin); B) CoA attached to sepharose through its primary amine at N6 (Amide-linked CoA resin); C) Other adenosine cofactors attached through the C8 of adenine. ATP, R = PPi; AMP, R = H, NAD+, R = nicotinamide mononucleotide.Back to article page