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Table 1 The correlations among evolutionary rate, the number of interactions, and protein abundance for all studies when abundance is measured by (A) mi-croarray expression level or (B) CAI. Np and Ni are the number of proteins and interactions for each data set. The Kendall's rank correlations between variables are given by τEI, τAI, and τEA. The Kendall's partial rank correlation between evolutionary rate and the number of interactions when abundance is controlled for is given by τEI.A. All correlations have two-tailed significances of P < 10-3 unless another P value is given in parentheses.

From: Apparent dependence of protein evolutionary rate on number of interactions is linked to biases in protein–protein interactions data sets

(A)
Study Np Ni τEI τAI τEA τEI.A
Ito [12] 505 1007 0.03 (0.30) -0.03 (0.36) -0.34 0.02 (0.51)
Uetz [13] 607 1183 0.01 (0.63) -0.01 (0.67) -0.35 0.01 (0.75)
2H studies [12, 13] 893 2034 0.02 (0.29) -0.02 (0.40) -0.36 0.02 (0.48)
Gavin [10] 1039 15224 -0.12 0.09 -0.45 -0.09
Gavin [10] untagged 1018 8568 -0.08 0.09 -0.44 -0.04 (0.04)
Ho [11] 1183 5879 -0.18 0.15 -0.41 -0.13
Ho [11] untagged 991 2990 -0.28 0.30 -0.40 -0.18
MS studies [10, 11] 1698 20708 -0.13 0.12 -0.42 -0.09
MS studies [10, 11] untagged 1543 11424 -0.14 0.16 -0.42 -0.08
synexpression [9] 1114 19188 0.09 -0.12 -0.40 0.05 (0.02)
gene neighborhood [9] 765 9882 -0.10 0.15 -0.44 -0.04 (0.15)
synthetic lethality [9] 524 1463 0.02 (0.50) 0.01 (0.71) -0.43 0.03 (0.40)
gene cooccurrence [9] 298 1718 -0.15 0.07 (0.08) -0.36 -0.13 (0.002)
gene fusion [9] 222 535 0.04 (0.40) -0.03 (0.51) -0.37 0.03 (0.56)
all interactions 2846 54258 -0.16 0.13 -0.39 -0.12
two studies 1112 2792 -0.17 0.14 -0.42 -0.13
three studies 329 556 0.03 (0.43) -0.03 (0.42) -0.36 0.02 (0.65)
(B)
Study Np Ni τEI τAI τEA τEI.A
Ito [12] 528 1049 0.03 (0.34) -0.04 (0.21) -0.31 0.02 (0.61)
Uetz [13] 630 1213 0.01 (0.65) -0.06 (0.02) -0.32 -0.01 (0.78)
2H studies [12, 13] 931 2104 0.02 (0.27) -0.06 (0.003) -0.33 0.00 (0.90)
Gavin [10] 1055 15836 -0.12 0.08 -0.38 -0.10
Gavin [10] untagged 1033 8648 -0.08 0.07 -0.37 -0.06 (0.01)
Ho [11] 1209 5941 -0.18 0.16 -0.42 -0.13
Ho [11] untagged 1013 3019 -0.28 0.33 -0.42 -0.16
MS studies [10, 11] 1735 20930 -0.13 0.11 -0.40 -0.10
MS studies [10, 11] untagged 1575 11531 -0.14 0.15 -0.40 -0.09
synexpression [9] 1163 20291 0.09 -0.09 -0.41 0.05 (0.06)
gene neighborhood [9] 790 10186 -0.09 0.08 -0.49 -0.06 (0.02)
synthetic lethality [9] 533 1505 0.03 (0.36) -0.02 (0.60) -0.38 0.02 (0.49)
gene cooccurrence [9] 309 1767 -0.14 0.07 (0.07) -0.44 -0.13 (0.02)
gene fusion [9] 233 559 0.04 (0.41) -0.01 (0.74) -0.40 0.03 (0.50)
all interactions 2960 56058 -0.16 0.12 -0.38 -0.13
two studies 1131 2822 -0.17 0.08 -0.41 -0.15
three studies 332 562 0.03 (0.45) -0.07 (0.06) -0.41 0.00 (0.99)