Table 1 The correlations among evolutionary rate, the number of interactions, and protein abundance for all studies when abundance is measured by (A) mi-croarray expression level or (B) CAI. Np and Ni are the number of proteins and interactions for each data set. The Kendall's rank correlations between variables are given by τEI, τAI, and τEA. The Kendall's partial rank correlation between evolutionary rate and the number of interactions when abundance is controlled for is given by τEI.A. All correlations have two-tailed significances of P < 10-3 unless another P value is given in parentheses.
(A) | ||||||
|---|---|---|---|---|---|---|
Study | Np | Ni | τEI | τAI | τEA | τEI.A |
Ito [12] | 505 | 1007 | 0.03 (0.30) | -0.03 (0.36) | -0.34 | 0.02 (0.51) |
Uetz [13] | 607 | 1183 | 0.01 (0.63) | -0.01 (0.67) | -0.35 | 0.01 (0.75) |
893 | 2034 | 0.02 (0.29) | -0.02 (0.40) | -0.36 | 0.02 (0.48) | |
Gavin [10] | 1039 | 15224 | -0.12 | 0.09 | -0.45 | -0.09 |
Gavin [10] untagged | 1018 | 8568 | -0.08 | 0.09 | -0.44 | -0.04 (0.04) |
Ho [11] | 1183 | 5879 | -0.18 | 0.15 | -0.41 | -0.13 |
Ho [11] untagged | 991 | 2990 | -0.28 | 0.30 | -0.40 | -0.18 |
1698 | 20708 | -0.13 | 0.12 | -0.42 | -0.09 | |
1543 | 11424 | -0.14 | 0.16 | -0.42 | -0.08 | |
synexpression [9] | 1114 | 19188 | 0.09 | -0.12 | -0.40 | 0.05 (0.02) |
gene neighborhood [9] | 765 | 9882 | -0.10 | 0.15 | -0.44 | -0.04 (0.15) |
synthetic lethality [9] | 524 | 1463 | 0.02 (0.50) | 0.01 (0.71) | -0.43 | 0.03 (0.40) |
gene cooccurrence [9] | 298 | 1718 | -0.15 | 0.07 (0.08) | -0.36 | -0.13 (0.002) |
gene fusion [9] | 222 | 535 | 0.04 (0.40) | -0.03 (0.51) | -0.37 | 0.03 (0.56) |
all interactions | 2846 | 54258 | -0.16 | 0.13 | -0.39 | -0.12 |
two studies | 1112 | 2792 | -0.17 | 0.14 | -0.42 | -0.13 |
three studies | 329 | 556 | 0.03 (0.43) | -0.03 (0.42) | -0.36 | 0.02 (0.65) |
(B) | ||||||
Study | Np | Ni | τEI | τAI | τEA | τEI.A |
Ito [12] | 528 | 1049 | 0.03 (0.34) | -0.04 (0.21) | -0.31 | 0.02 (0.61) |
Uetz [13] | 630 | 1213 | 0.01 (0.65) | -0.06 (0.02) | -0.32 | -0.01 (0.78) |
931 | 2104 | 0.02 (0.27) | -0.06 (0.003) | -0.33 | 0.00 (0.90) | |
Gavin [10] | 1055 | 15836 | -0.12 | 0.08 | -0.38 | -0.10 |
Gavin [10] untagged | 1033 | 8648 | -0.08 | 0.07 | -0.37 | -0.06 (0.01) |
Ho [11] | 1209 | 5941 | -0.18 | 0.16 | -0.42 | -0.13 |
Ho [11] untagged | 1013 | 3019 | -0.28 | 0.33 | -0.42 | -0.16 |
1735 | 20930 | -0.13 | 0.11 | -0.40 | -0.10 | |
1575 | 11531 | -0.14 | 0.15 | -0.40 | -0.09 | |
synexpression [9] | 1163 | 20291 | 0.09 | -0.09 | -0.41 | 0.05 (0.06) |
gene neighborhood [9] | 790 | 10186 | -0.09 | 0.08 | -0.49 | -0.06 (0.02) |
synthetic lethality [9] | 533 | 1505 | 0.03 (0.36) | -0.02 (0.60) | -0.38 | 0.02 (0.49) |
gene cooccurrence [9] | 309 | 1767 | -0.14 | 0.07 (0.07) | -0.44 | -0.13 (0.02) |
gene fusion [9] | 233 | 559 | 0.04 (0.41) | -0.01 (0.74) | -0.40 | 0.03 (0.50) |
all interactions | 2960 | 56058 | -0.16 | 0.12 | -0.38 | -0.13 |
two studies | 1131 | 2822 | -0.17 | 0.08 | -0.41 | -0.15 |
three studies | 332 | 562 | 0.03 (0.45) | -0.07 (0.06) | -0.41 | 0.00 (0.99) |