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Table 2 Statistical significance of the differences in evolutionary rates between groups of proteins with different numbers of interactions.

From: No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly

Bin (# interactions) comparisons a Pb
S. cerevisiaeS. pombe
41 – 60 vs. 1 – 40 8.3 × 10-4
31 – 60 vs. 1 – 30 2.4 × 10-2
21 – 60 vs. 1 – 20 1.7 × 10-4
H. pylori 26695H. pylori J99
21 – 55 vs. 1 – 20 1.5 × 10-1
15 – 55 vs. 1 – 14 1.8 × 10-1
11 – 55 vs. 1 – 10 3.2 × 10-1
H. pylori 26695C. jejuni
21 – 47 vs. 1 – 20 9.8 × 10-1
11 – 47 vs. 1 – 10 5.1 × 10-1
  1. a Orthologous pairs of proteins were placed into bins based on the number of protein-protein interactions (Figure 3). b P-value for the Student's ttest comparing the mean evolutionary rates between orthologs for bins with distinct ranges in the number of protein-protein interactions.