TY - JOUR AU - Jordan, I. King AU - Wolf, Yuri I. AU - Koonin, Eugene V. PY - 2003 DA - 2003/01/06 TI - No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly JO - BMC Evolutionary Biology SP - 1 VL - 3 IS - 1 AB - It has been suggested that rates of protein evolution are influenced, to a great extent, by the proportion of amino acid residues that are directly involved in protein function. In agreement with this hypothesis, recent work has shown a negative correlation between evolutionary rates and the number of protein-protein interactions. However, the extent to which the number of protein-protein interactions influences evolutionary rates remains unclear. Here, we address this question at several different levels of evolutionary relatedness. SN - 1471-2148 UR - https://doi.org/10.1186/1471-2148-3-1 DO - 10.1186/1471-2148-3-1 ID - Jordan2003 ER -