Table 2 List of SNP containing candidate genes included in the population genetic analysis

Aryl hydrocarbon receptor 1

1743961[uid]

transcription factor, response to xenobiotic stimulus

[7]

Aryl hydrocarbon receptor 2

1743966[uid]

transcription factor, response to xenobiotic stimulus

[8]

Aryl hydrocarbon receptor 2b

N/A

transcription factor, response to xenobiotic stimulus

Karchner & Hahn, unpublished;

Aryl hydrocarbon receptor repressor

1743962[uid]

signal transducer, response to xenobiotic stimulus

[25]

Atrial natriuretic peptide

1743159[uid]

receptor binding, cardiac muscle hypertrophy in response to stress

[26]

Aldehyde dehydrogenase family 9 member A1

1741825[uid]

oxidoreductase activity, retinoic acid metabolic process

[27]

Cardiac myosin light chain-1

1741781[uid]

calcium ion binding, cardiac muscle tissue development

Cathepsin E precursor

1744072[uid]

endopeptidase, antigen processing

Cathepsin F precursor

1741927[uid]

cysteine-type peptidase activity

Cathepsin Z precursor

2476770[uid]

cysteine-type peptidase activity, angiogenesis

Complement Component C3

1742328[uid]

protein binding, lipid binding, endopeptidase inhibitor, innate immune response, regulation of angiogenesis

[28]

Cytochrome p450 1A

2476796[uid]

oxidoreductase activity, dibenzo-p-dioxin catabolic process

[11, 29–31]

Cytochrome p450 3A30

1742582[uid]

oxidoreductase activity, response to xenobiotic stimulus

[28]

Cytochrome B5

1743444[uid]

enzyme binding, heme binding, oxidation reduction process

[29–31]

Estrogen Receptor alpha

1743972[uid]

estrogen receptor activity, transcription factor binding, response to estradiol stimulus, regulation of retinoic acid receptor signalling pathway

[32]

Estrogen Receptor beta a

2301213[uid]

estrogen receptor activity, estrogen response element binding, response to estradiol stimulus, regulation of transcription factor activity

[32]

Glyceraldehyde 3 phosphate dehydrogenase

1742899[uid]

oxidation reduction process

Hepcidin

1744101[uid]

hormone activity, defense response

Hepcidin 2

N/A

Karchner & Hahn, unpublished

Heatshock protein 90 beta

1743580[uid]

protein binding, response to stress

Plasma Kallikrein precursor

1742469[uid]

peptidase activity, proteolysis, hemostasis

Kallikrein

N/A

Karchner & Hahn, unpublished

Myosin Light chain 2

1743984[uid]

actin monomer binding, heart development

[29]

Myosin Light chain alkali, smooth muscle

1743182[uid]

structural constituent of muscle, muscle contraction

NADH [ubiquinone] dehydrogenase 1 alpha subcomplex subuint 4

1743852[uid]

electron transport chain

[28]

Myosin regulatory light chain 3

1741657[uid]

calcium ion binding

NADH dehydrogenase subunit 1

3014035[uid]

oxidoreductase activity

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1743800[uid]

electron transport chain

[33]

NADH dehydrogenase subunit 2

1742301[uid]

oxidoreductase activity

NADH dehydrogenase subunit 3

1742764[uid]

oxidoreductase activity

NADH dehydrogenase subunit 4

1741822[uid]

oxidoreductase activity

NADH dehydrogenase subunit 6

3014152[uid]

oxidoreductase activity

Platelet Coagulation Factor XI

3014242[uid]

peptidase activity, proteolysis, hemostasis

[28]

Retinoic Acid Receptor Responder Protein 1

1743266[uid]

negative regulation of cell proliferation

Retinoic Acid Receptor Responder Protein 3

1741754[uid]

negative regulation of cell proliferation

Rho-class Glutathione S-Transferase

1743333[uid]

transferase activity

[30, 31, 34]

Serine Protease Inhibitor

N/A

negative regulation of endopeptidase activity

Karchner & Hahn, unpublished

TBT Binding Protein

1741555[uid]

response to xenobiotic stimulus

[28]

Thioredoxin

1743303[uid]

protein binding, oxidoreductase activity

[33]

Translation Initiation Factor 2

1744423[uid]

ligand-dependent nuclear receptor binding, estrogen receptor binding, retinoic acid receptor binding, signal transduction

Telethonin (Titin cap protein)

1743784[uid]

heart development, cardiac muscle contraction, sarcomere organization, response to stress

[29]

Cardiac Troponin T2

1742146[uid]

actin binding, tropomyosin binding, troponin binding, cardiac muscle morphogenesis, sarcomere organization, muscle filament sliding

[26, 29, 35]

Ubiquitin A-52 residue ribosomal protein fusion product 1

1744070[uid]

structural constituent of ribosome, translation