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Table 2 List of SNP containing candidate genes included in the population genetic analysis

From: Targeted approach to identify genetic loci associated with evolved dioxin tolerance in Atlantic Killifish (Fundulus heteroclitus)

Gene name Unigene ID Putative function Reference
Aryl hydrocarbon receptor 1 1743961[uid] transcription factor, response to xenobiotic stimulus [7]
Aryl hydrocarbon receptor 2 1743966[uid] transcription factor, response to xenobiotic stimulus [8]
Aryl hydrocarbon receptor 2b N/A transcription factor, response to xenobiotic stimulus Karchner & Hahn, unpublished;
Aryl hydrocarbon receptor repressor 1743962[uid] signal transducer, response to xenobiotic stimulus [25]
Atrial natriuretic peptide 1743159[uid] receptor binding, cardiac muscle hypertrophy in response to stress [26]
Aldehyde dehydrogenase family 9 member A1 1741825[uid] oxidoreductase activity, retinoic acid metabolic process [27]
Cardiac myosin light chain-1 1741781[uid] calcium ion binding, cardiac muscle tissue development  
Cathepsin E precursor 1744072[uid] endopeptidase, antigen processing  
Cathepsin F precursor 1741927[uid] cysteine-type peptidase activity  
Cathepsin Z precursor 2476770[uid] cysteine-type peptidase activity, angiogenesis  
Complement Component C3 1742328[uid] protein binding, lipid binding, endopeptidase inhibitor, innate immune response, regulation of angiogenesis [28]
Cytochrome p450 1A 2476796[uid] oxidoreductase activity, dibenzo-p-dioxin catabolic process [11, 2931]
Cytochrome p450 3A30 1742582[uid] oxidoreductase activity, response to xenobiotic stimulus [28]
Cytochrome B5 1743444[uid] enzyme binding, heme binding, oxidation reduction process [2931]
Estrogen Receptor alpha 1743972[uid] estrogen receptor activity, transcription factor binding, response to estradiol stimulus, regulation of retinoic acid receptor signalling pathway [32]
Estrogen Receptor beta a 2301213[uid] estrogen receptor activity, estrogen response element binding, response to estradiol stimulus, regulation of transcription factor activity [32]
Glyceraldehyde 3 phosphate dehydrogenase 1742899[uid] oxidation reduction process  
Hepcidin 1744101[uid] hormone activity, defense response  
Hepcidin 2 N/A   Karchner & Hahn, unpublished
Heatshock protein 90 beta 1743580[uid] protein binding, response to stress  
Plasma Kallikrein precursor 1742469[uid] peptidase activity, proteolysis, hemostasis  
Kallikrein N/A   Karchner & Hahn, unpublished
Myosin Light chain 2 1743984[uid] actin monomer binding, heart development [29]
Myosin Light chain alkali, smooth muscle 1743182[uid] structural constituent of muscle, muscle contraction  
NADH [ubiquinone] dehydrogenase 1 alpha subcomplex subuint 4 1743852[uid] electron transport chain [28]
Myosin regulatory light chain 3 1741657[uid] calcium ion binding  
NADH dehydrogenase subunit 1 3014035[uid] oxidoreductase activity  
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1743800[uid] electron transport chain [33]
NADH dehydrogenase subunit 2 1742301[uid] oxidoreductase activity  
NADH dehydrogenase subunit 3 1742764[uid] oxidoreductase activity  
NADH dehydrogenase subunit 4 1741822[uid] oxidoreductase activity  
NADH dehydrogenase subunit 6 3014152[uid] oxidoreductase activity  
Platelet Coagulation Factor XI 3014242[uid] peptidase activity, proteolysis, hemostasis [28]
Retinoic Acid Receptor Responder Protein 1 1743266[uid] negative regulation of cell proliferation  
Retinoic Acid Receptor Responder Protein 3 1741754[uid] negative regulation of cell proliferation  
Rho-class Glutathione S-Transferase 1743333[uid] transferase activity [30, 31, 34]
Serine Protease Inhibitor N/A negative regulation of endopeptidase activity Karchner & Hahn, unpublished
TBT Binding Protein 1741555[uid] response to xenobiotic stimulus [28]
Thioredoxin 1743303[uid] protein binding, oxidoreductase activity [33]
Translation Initiation Factor 2 1744423[uid] ligand-dependent nuclear receptor binding, estrogen receptor binding, retinoic acid receptor binding, signal transduction  
Telethonin (Titin cap protein) 1743784[uid] heart development, cardiac muscle contraction, sarcomere organization, response to stress [29]
Cardiac Troponin T2 1742146[uid] actin binding, tropomyosin binding, troponin binding, cardiac muscle morphogenesis, sarcomere organization, muscle filament sliding [26, 29, 35]
Ubiquitin A-52 residue ribosomal protein fusion product 1 1744070[uid] structural constituent of ribosome, translation  
  1. Note: Potential involvement of each gene in toxic DLC response was demonstrated in citations listed in ‘Reference’ column.
  2. N/A = not available.