Figure 4

Antigenicity and intrinsic protein disorder. Variations in antigenicity (A) for each group as predicted by the VaxiJen server [55] that uses an alignment-independent algorithm based on the physicochemical properties of proteins [55]. Ratio of disordered compared to the total sequence (B) for each group as predicted by the MetaDisorder server that builds a consensus from 13 protein disorder predictors [56]. Panel C shows the correlation for G4 between antigenicity (x-axis) and intrinsic protein disorder (y-axis).