Figure 4

Results of LRH test. (a) REHH plots of the core region covering the --^SEA allele in CRS dataset. The values are plotted against the genetic distance from the selected core region. The plot of core haplotype containing --^SEA is indicated by the solid yellow line. (b) The empirical distribution of REHH value of SNPs at a distance of 0.35 cM on chromosome 16. Only those alleles with population frequency between 0.031 and 0.042 in the CHS were considered. The REHH value of --^SEA is indicated by the dashed line. (c) The plot of cumulative frequency of REHH value of 1000 constructed random samples vs. that of CHS. Most of the REHH values of 1000 CRS (~60%) were within the 5% extreme high value of REHH in CHS.