Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection

Table 1 Significant recombination events detected among NAT genes using six different methods

Species	Genes	5' breakpoint^a	3' breakpoint^a	Length (bp)^a	P-value range^b	Methods^b
Rattus norvegicus	NAT1 : NAT2	382/385/401	609/611	209/225/230	9.06 E-3–1.00 E-6	GeneConv, RDP, MaxChi, Chimaera, Bootscan, SiScan
Oryzias latipes	NAT1 : NAT2	1	260/262	260/262	8.87 E-3–6.39 E-6	Geneconv, RDP, MaxChi, Chimaera, Bootscan
Echinops telfairi	NAT1 : NAT2	43	642	600	1.00 E-4	Geneconv
Myotis lucifugus	NAT1 : NAT2	600/615	742/749	128/150	6.06 E-4–1.39 E-4	MaxChi, Chimaera,
Mus musculus	NAT1 : NAT2	382	518	137	2.00 E-4	Geneconv
Mesocricetus auratus	NAT1 : NAT2	1	155/163/167	155/163/167	9.32 E-3–2.93 E-4	RDP, Chimaera, Bootscan, SiScan
Myotis lucifugus	NAT1 : NAT2	1	204	204	3.00 E-4	Geneconv
Danio rerio	NAT2 : NAT3	88	507	420	7.90 E-3	Geneconv

^a Breakpoint positions refer to the nt positions in the full alignment of the vertebrate NAT sequences. They may slightly vary depending on the method used to detect recombinant sequences, leading to different gene conversion tract lengths.
^b In cases where multiple methods detected the same or a similar conversion event, we reported the P-value range, i.e. the worst and the best P-value; the method yielding the best P-value is shown in bold. Otherwise, only the P-value of the single algorithm detecting a conversion event is presented.

ISSN: 2730-7182