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Table 2 Nuclear export and localization signals in Sirtuin family

From: Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

PROTEIN

SIRT1

SIRT2

SIRT3

SIRT4

SIRT5

SIRT6

SIRT7

N-terminal

NES

NES

NES

NES

NES

NES

NES

 

NLS

      

C-terminal

    

NES ( ciona )

 

NES ( ciona )

  1. NES or NLS indicates the presence of the signal in a specific group of Sirtuins. No NLS signal has been found in the C-terminal segments.